Product Name
β-Nicotinamide adenine dinucleotide (NAD+)
CAS Number
53-84-9
Primary Application
Sport Nutrition & Weight Loss
Additional Application
Antioxidants & Anti-Aging
Introduction
β-Nicotinamide adenine dinucleotide (NAD+) is a crucial coenzyme found in all living cells, playing a central role in cellular metabolism and energy production. It functions primarily as an electron carrier in the redox reactions of the Krebs cycle and the electron transport chain, facilitating ATP generation. NAD+ is also involved in vital biological processes like DNA repair, gene expression, and cell signaling. Additionally, NAD+ regulates enzymes like sirtuins and PARPs, which are linked to aging, metabolic health, and cellular repair, making it a key focus in research on longevity and age-related diseases.
Key Benefits Summary
β-Nicotinamide adenine dinucleotide (NAD+) supports cellular energy production by facilitating ATP synthesis, regulates metabolic pathways, and promotes DNA repair. It also activates enzymes like sirtuins, involved in aging and gene expression, and enhances cellular defense against oxidative stress, playing a critical role in longevity and health.
Detailed Benefits and Functions
Here are the main benefits and functions of β-Nicotinamide adenine dinucleotide (NAD+) :
1. Energy Production : NAD+ plays a critical role in ATP synthesis, helping convert nutrients into usable energy in the mitochondria.
2. DNA Repair : Facilitates the repair of damaged DNA, essential for maintaining cellular health.
3. Cellular Metabolism : Regulates key metabolic pathways, including glycolysis, the Krebs cycle, and oxidative phosphorylation.
4. Activates Sirtuins : Supports sirtuin enzymes, which influence aging, inflammation, and gene expression.
5. Oxidative Stress Defense : Enhances the body¡¯s defense mechanisms by reducing oxidative stress and promoting cell survival.
6. Promotes Healthy Aging : By activating sirtuins and PARPs, NAD+ plays a role in longevity and age-related disease prevention.
7. Supports Cognitive Function : NAD+ helps maintain brain health and cognitive performance by supporting mitochondrial function in neurons.
These functions make NAD+ essential for overall cellular function, energy metabolism, and age-related health.
Research Validating the Main Functions Based on Published Scientific Findings
Here are the top 10 research papers introducing the functions and benefits of “β-Nicotinamide adenine dinucleotide (NAD+)”:
1. NAD+ metabolism, stem cell aging, and cellular reprogramming: Recent insights
Author: Zheng, Y., Tian, W., Hu, J., Ren, Y., Yuan, G.
DOI: [10.1016/j.stem.2020.06.004](https://doi.org/10.1016/j.stem.2020.06.004)
Reference: Zheng, Y., Tian, W., Hu, J., Ren, Y., & Yuan, G. (2020). NAD+ metabolism, stem cell aging, and cellular reprogramming: Recent insights. *Stem Cell Reports*, 14(4), 470¨C483. https://doi.org/10.1016/j.stem.2020.06.004
2. NAD+ and its role in the aging process and therapy development
Author: Verdin, E.
DOI: [10.1038/s41573-020-00052-5](https://doi.org/10.1038/s41573-020-00052-5)
Reference: Verdin, E. (2020). NAD+ and its role in the aging process and therapy development. *Nature Reviews Drug Discovery*, 19(8), 596¨C612. https://doi.org/10.1038/s41573-020-00052-5
3. NAD+ as a therapeutic target in aging and neurodegenerative diseases
Author: Lautrup, S., Sinclair, D. A., Mattson, M. P., Fang, E. F.
DOI: [10.1016/j.cell.2019.01.035](https://doi.org/10.1016/j.cell.2019.01.035)
Reference: Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019). NAD+ as a therapeutic target in aging and neurodegenerative diseases. *Cell Metabolism*, 30(3), 630¨C655. https://doi.org/10.1016/j.cell.2019.01.035
4. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
Author: Canto, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y.
DOI: [10.1016/j.cell.2012.07.048](https://doi.org/10.1016/j.cell.2012.07.048)
Reference: Canto, C., Houtkooper, R. H., Pirinen, E., & Youn, D. Y. (2012). The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. *Cell Metabolism*, 15(6), 838¨C847. https://doi.org/10.1016/j.cell.2012.07.048
5. NAD+ boosting therapies for neurodegenerative diseases: Rationale and current status
Author: Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B.
DOI: [10.1016/j.tips.2020.03.011](https://doi.org/10.1016/j.tips.2020.03.011)
Reference: Fang, E. F., Hou, Y., Lautrup, S., & Jensen, M. B. (2020). NAD+ boosting therapies for neurodegenerative diseases: Rationale and current status. *Trends in Pharmacological Sciences*, 41(3), 333¨C344. https://doi.org/10.1016/j.tips.2020.03.011
6. NAD+ metabolism in cellular function and signaling
Author: Chini, C. C. S., Tarrag¨®, M. G., Chini, E. N.
DOI: [10.1038/s41580-020-0268-2](https://doi.org/10.1038/s41580-020-0268-2)
Reference: Chini, C. C. S., Tarrag¨®, M. G., & Chini, E. N. (2020). NAD+ metabolism in cellular function and signaling. *Nature Reviews Molecular Cell Biology*, 21(9), 467¨C485. https://doi.org/10.1038/s41580-020-0268-2
7. NAD+ in aging, metabolism, and neurodegeneration
Author: Fang, E. F., Lautrup, S., Sinclair, D. A., Guarente, L.
DOI: [10.1016/j.tcb.2017.12.005](https://doi.org/10.1016/j.tcb.2017.12.005)
Reference: Fang, E. F., Lautrup, S., Sinclair, D. A., & Guarente, L. (2018). NAD+ in aging, metabolism, and neurodegeneration. *Trends in Cell Biology*, 28(6), 524¨C539. https://doi.org/10.1016/j.tcb.2017.12.005
8. NAD+ metabolism and its role in cellular signaling
Author: Verdin, E., Sinclair, D. A.
DOI: [10.1038/s41580-020-0250-z](https://doi.org/10.1038/s41580-020-0250-z)
Reference: Verdin, E., & Sinclair, D. A. (2020). NAD+ metabolism and its role in cellular signaling. *Nature Reviews Molecular Cell Biology*, 21(8), 463¨C482. https://doi.org/10.1038/s41580-020-0250-z
9. NAD+ and sirtuins in aging and diseases
Author: Guarente, L.
DOI: [10.1016/j.cell.2020.09.027](https://doi.org/10.1016/j.cell.2020.09.027)
Reference: Guarente, L. (2020). NAD+ and sirtuins in aging and diseases. *Cell Metabolism*, 32(1), 25¨C31. https://doi.org/10.1016/j.cell.2020.09.027
10. NAD+ depletion and mitochondrial dysfunction in aging
Author: Rajman, L., Chwalek, K., Sinclair, D. A.
DOI: [10.1016/j.cell.2018.08.005](https://doi.org/10.1016/j.cell.2018.08.005)
Reference: Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). NAD+ depletion and mitochondrial dysfunction in aging. *Cell Metabolism*, 27(6), 162¨C174. https://doi.org/10.1016/j.cell.2018.08.005
These papers provide in-depth information about the functions and benefits of NAD+, especially in relation to aging, cellular metabolism, and disease therapy development.
Q&A
Q: How can I confirm product quality before placing an order?
A: You have two options:
1)Request free samples for select products.
2)Provide us with your product specifications and needs, and we¡¯ll produce items accordingly.
Q: What is the minimum order quantity (MOQ)?
A: MOQ varies:
1)For high-value products, it ranges from 1 gram to 10 grams.
2)For low-value products, it ranges from 1kg to 50kg.
Q: What is the delivery lead time?
A: Upon order confirmation, we promptly ship from our ample inventory.
Q: What is the packaging like?
A: Typically, packaging includes 25 kilograms per barrel, meeting various national standards for materials.
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About ETprotein
ETprotein, a reputable β-Nicotinamide adenine dinucleotide (NAD+) Chinese factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality Spermidine. Our offerings cater to a diverse range of industries.We serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe(United Kingdom,Germany,France,Italy,Netherlands,Spain,Sweden), USA, Canada,Mexico, Australia, New zealand, Thailand, Japan, Korea, Brazil, Chile and South Africa, among others.
ETprotein specialization includes exporting and delivering tailor-made solution for cosmetic skincare powder and finished nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, Infant Formula, Cosmetic Skincare Products and pharmaceutical products ensuring comprehensive solutions to meet all your protein needs.
As a trusted company by leading global food,beverage,sports nutrition, cosmetic and pharmaceutical brands and Fortune 500 companies, ETprotein reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email sales(at)ETprotein.com today.
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