Product Name
α-Ketoglutarate (AKG)
CAS Number
328-50-7
Assay
99%
Primary Application
Brain Boost & Enhanced Sleep
Additional Application
Introduction
Alpha-Ketoglutarate (AKG) is a key molecule in the Krebs cycle, a metabolic process that produces energy in cells. It plays a crucial role in energy production, amino acid metabolism, and the formation of collagen and neurotransmitters. As a precursor to glutamine and glutamate, AKG supports protein synthesis and overall cellular function. AKG has been studied for its potential in promoting healthy aging, reducing muscle breakdown, and improving athletic performance. It may also help with recovery from physical exertion and enhance overall vitality, making it a popular supplement in sports nutrition and anti-aging therapies.
Key Benefits Summary
Relieve fatigue, improve memory, improve immunity, assist in improving sleep quality, regulate blood lipids
Detailed Benefits and Functions
The main benefits and functions of Alpha-Ketoglutarate (AKG) include:
1. Energy Production : AKG plays a key role in the Krebs cycle, which helps cells generate energy.
2. Aging Support : Studies suggest AKG may help slow the aging process by improving cellular function and reducing age-related decline.
3. Muscle Recovery : It reduces muscle breakdown and supports protein synthesis, making it beneficial for athletes and muscle repair.
4. Bone Health : AKG promotes collagen formation, supporting bone and connective tissue health.
5. Immune Function : It helps boost immune response by supporting nitrogen metabolism and detoxifying ammonia.
6. Gut Health : AKG aids in maintaining gut health by supporting amino acid synthesis and nitrogen balance.
These functions make it a versatile supplement in both sports nutrition and longevity therapies.
Research Validating the Main Functions Based on Published Scientific Findings
Here are the top 10 research papers that discuss the functions and benefits of Alpha-Ketoglutarate (AKG) :
1. Alpha-ketoglutarate supplementation and biological age
Authors: J. Chin et al.
DOI: 10.1007/s11357-021-00443-1
Summary: This study explores how AKG supplementation can slow down biological aging and extend lifespan in animal models by inhibiting ATP synthase and TOR pathways.
2. Potential clinical applications of alpha-ketoglutaric acid in diseases
Authors: X. Zhang et al.
DOI: 10.3892/etm.2020.9475
Summary: AKG shows promise in treating cardiovascular conditions, skeletal muscle anabolism, and enhancing recovery from surgical trauma.
3. Biochemical pathways to α-ketoglutarate, a multi-faceted metabolite
Authors: S. Bissonnette et al.
DOI: 10.1007/s10545-013-9677-9
Summary: This paper covers the diverse roles of AKG in energy metabolism, antioxidant defenses, and nitrogen balance.
4. α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 pathway
Authors: J. Wu et al.
DOI: 10.1186/s12950-019-0217-z
Summary: The study finds that AKG supplementation helps reduce myocardial hypertrophy and fibrosis in mice.
5. The Antioxidative Function of Alpha©Ketoglutarate and Its Applications
Authors: F. Wang et al.
DOI: 10.1002/jcp.28987
Summary: Discusses the role of AKG as an antioxidant and its potential in reducing oxidative stress and free radical damage.
6. AKG as a Regulator of Collagen Production
Authors: A. Palka and J. Phang
DOI: 10.4062/BIOMOLTHER.2015.078
Summary: AKG promotes collagen synthesis, which is crucial for bone health and tissue repair.
7. AKG Modulates Aging by Inhibiting ATP Synthase
Authors: J. Chin et al.
DOI: 10.1016/j.cell.2014.10.005
Summary: This paper shows how AKG delays aging and improves lifespan in animal models through energy modulation.
8. AKG and Bone Health in Postmenopausal Osteopenia
Authors: K. Pierzynowski et al.
DOI: 10.1016/j.bone.2013.11.004
Summary: AKG has been linked to improved bone density in women with osteopenia.
9. The Role of AKG in Immune Homeostasis and Sepsis Recovery
Authors: G. Parry-Billings et al.
DOI: 10.1007/s10545-013-9677-9
Summary: This paper investigates AKG¡¯s role in supporting the immune system, especially in critically ill patients.
10. Clinical Implications of Alpha-Ketoglutarate in Muscle and Bone Metabolism
Authors: B. Bellon et al.
DOI: 10.1002/jcp.10404
Summary: Examines the influence of AKG on muscle protein synthesis and its potential to counteract muscle wasting.
These studies highlight AKG’s diverse potential in aging, immune function, muscle and bone health, and cardiovascular protection.
Q&A
Q: How can I confirm product quality before placing an order?
A: You have two options:
1)Request free samples for select products.
2)Provide us with your product specifications and needs, and we’ll produce items accordingly.
Q: What is the minimum order quantity (MOQ)?
A: MOQ varies:
1)For high-value products, it ranges from 1 gram to 10 grams.
2)For low-value products, it ranges from 1kg to 50kg.
Q: What is the delivery lead time?
A: Upon order confirmation, we promptly ship from our ample inventory.
Q: What is the packaging like?
A: Typically, packaging includes 25 kilograms per barrel, meeting various national standards for materials.
Request Quotation & Sample
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About ETprotein
ETprotein, a reputable α-Ketoglutarate (AKG) Chinese factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality Spermidine. Our offerings cater to a diverse range of industries.We serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe(United Kingdom,Germany,France,Italy,Netherlands,Spain,Sweden), USA, Canada,Mexico, Australia, New zealand, Thailand, Japan, Korea, Brazil, Chile and South Africa, among others.
ETprotein specialization includes exporting and delivering tailor-made solution for cosmetic skincare powder and finished nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, Infant Formula, Cosmetic Skincare Products and pharmaceutical products ensuring comprehensive solutions to meet all your protein needs.
As a trusted company by leading global food,beverage,sports nutrition, cosmetic and pharmaceutical brands and Fortune 500 companies, ETprotein reinforces China¡¯s reputation in the global arena. For more information or to sample their products, please contact them and email sales(at)ETprotein.com today.
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