• Table of Contents

  • 13-Cis Retinoic Acid vs. Isotretinoin: Understanding the Differences
  • Introduction to Retinoids
  • What is 13-Cis Retinoic Acid?
  • Understanding Isotretinoin
  • Comparing 13-Cis Retinoic Acid and Isotretinoin
  • Medical Uses and Benefits
  • Side Effects and Risks
  • Conclusion: Key Takeaways
  • Explore ETprotein’s Protein Products

13-Cis Retinoic Acid vs. Isotretinoin: Understanding the Differences

Retinoids have revolutionized the treatment of acne and other skin conditions, with 13-cis retinoic acid and isotretinoin being prominent names in the field. Despite their similar chemical structures and uses, these compounds have distinct characteristics and applications. This article delves into the differences between 13-cis retinoic acid and isotretinoin, providing a comprehensive understanding of their functions, benefits, and side effects.

Introduction to Retinoids

Retinoids are a class of chemical compounds that are vitamers of vitamin A or are chemically related to it. They are used in medicine to regulate epithelial cell growth. Retinoids have many important functions throughout the body including roles in vision, regulation of cell proliferation and differentiation, growth of bone tissue, immune function, and activation of tumor suppressor genes.

What is 13-Cis Retinoic Acid?

13-cis retinoic acid, also known as isotretinoin or by its brand name Accutane, is a medication primarily used to treat severe acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is derived from vitamin A and is found in small quantities naturally in the body.

Understanding Isotretinoin

Isotretinoin, also known as 13-cis-retinoic acid, is a medication used mostly for cystic acne. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly. Isotretinoin is a form of vitamin A and is part of the retinoid family.

Comparing 13-Cis Retinoic Acid and Isotretinoin

Although 13-cis retinoic acid and isotretinoin are often discussed interchangeably, they refer to the same chemical compound. The confusion typically arises from the different names used in various studies and articles. Here, we clarify that they are identical substances with the same chemical formula and molecular structure.

Medical Uses and Benefits

• Acne Treatment: Both compounds are renowned for their effectiveness in treating severe nodular acne that has not responded to other treatments.
• Skin Cancer Prevention: They have been used in trials for preventing skin cancers, showing promising results in reducing cancer incidence.
• Other Dermatological Uses: These compounds are also used in the treatment of other skin diseases such as ichthyosis and psoriasis.

Side Effects and Risks

Despite their benefits, isotretinoin and 13-cis retinoic acid carry significant risks and side effects, which include:

• Teratogenicity: Extremely high risk of birth defects if taken during pregnancy, hence stringent measures are in place to avoid pregnancy during treatment.
• Mental Health Risks: There have been reports of depression and suicidal thoughts, although a direct link has not been conclusively established.
• Other Side Effects: Dry skin, lips, and eyes; muscle aches; and increased triglyceride levels in the blood.

Conclusion: Key Takeaways

In conclusion, while 13-cis retinoic acid and isotretinoin might appear as different entities in some contexts, they are essentially the same compound used interchangeably in dermatology. They offer significant benefits for severe acne treatment and potential cancer prevention but come with notable risks that require careful management under professional guidance.

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Isotretinoin Product Page

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About ETprotein

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