ErgoElite™
L-(+)-Ergothioneine EGT Food Grade 99.5%
Chinese Supplier Factory Manufacturer
Guardian Cell Vitamin!
DNA Level!
What is ErgoELite™ L-(+)-Ergothioneine (EGT) Food Grade?
L-Ergothioneine is a naturally occurring amino acid, recognized for its antioxidant properties and health benefits. Found in foods like mushrooms and meats, it helps protect cells from oxidative stress and is essential for maintaining health.In food nutrition, L-Ergothioneine enhances food quality and extends shelf life by preventing oxidative damage. In sports nutrition, it supports athletes by reducing oxidative stress, aiding in faster recovery, and improving performance. Its benefits make it a valuable addition to both food products and sports supplements, promoting health and optimal physical function.
ETProtein, a leading innovator and supplier, has significantly reduced EGT’s cost, broadening its accessibility in food&supplements industries. We are dedicated to delivering the king of antioxidants through our brand ErgoElite™ worldwide, ensuring everyone can experience its beauty benefits. Please contact us for more information today!
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What is L-(+)-Ergothioneine EGT? ErgoElite™ Purity>99.0% Food Grade
What is L-(+)-Ergothioneine EGT?
Ergothioneine, a sulfur-containing derivative of histidine, has gained attention for its excellent antioxidant properties, making it widely used in food and cosmetics. It efficiently neutralizes reactive oxygen species and inhibits lipid peroxidation. Studies have also revealed its roles in scavenging free radicals, detoxification, DNA biosynthesis, and enhancing cell-mediated immunity. It offers protective functions, including anti-aging. Ergothioneine, as a natural antioxidant, is applied in pharmaceuticals, cosmetics, and food industries, benefiting from its multiple health-protective effects.
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Bruce Ames
Cancer and anti-aging expert biochemist
Professor, Department of Biochemistry and Molecular Biology, University of California
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Longevity Nutrient Proceedings of the National Academy of Sciences (PNAS)
Ergothioneine (EGT) is a potent natural antioxidant that prevents or mitigates free radical damage, protecting DNA and proteins from oxidative harm and maintaining cellular health. It offers anti-inflammatory benefits, prevents cardiovascular diseases, slows skin aging, protects against UV damage, and delays aging. Bruce Ames, a member of the National Academy of Sciences, a cancer and anti-aging expert, and a professor in the Department of Biochemistry and Molecular Biology at the University of California, has dubbed ergothioneine a “longevity nutrient.”
What is the Science behind
ErgoElite™ L-(+)-Ergothioneine EGT?
What distinguishes ErgoElite™ L-(+)-Ergothioneine from other antioxidants in combating cellular aging?
Antioxidants Capable of Mitochondrial Penetration <br>Activation of Endogenous Antioxidant Systems
Ergothioneine stands out among natural antioxidants for its unique ability to penetrate both the mitochondria and the cell nucleus, a capability attributed to its well-defined mechanism of action. This distinctiveness is primarily due to the presence of the specific transport protein OCTN1 on keratinocytes and fibroblasts within the skin, allowing Ergothioneine to traverse cell membranes and enter cell mitochondria directly. Upon entry, it effectively neutralizes reactive oxygen free radicals, thus playing a pivotal role in mitigating oxidative stress.
From the perspective of cellular aging, the process is largely driven by the accumulation of oxidative substances produced within the mitochondria. These substances gradually damage the cell membrane, leading to cell apoptosis. Addressing oxidative damage at the mitochondrial level is therefore crucial in combating aging. Ergothioneine, through its targeted interaction with OCTN1, not only purges these harmful free radicals but also activates other antioxidant enzymes, such as glutathione peroxidase and superoxide dismutase. These enzymes are instrumental in scavenging reactive oxygen species (ROS), thereby synergistically amplifying the antioxidant defense mechanism within cells.
Moreover, Ergothioneine\’s ability to initiate a cooperative response among various antioxidant components exemplifies its exceptional efficacy. It not only acts directly against oxidative threats but also empowers the cell\’s endogenous antioxidant system, thereby embodying a leadership quality in the realm of antioxidant defense. This multifaceted approach positions Ergothioneine as a potent force against cellular aging, offering a comprehensive strategy to enhance the cell\’s inherent antioxidative capacity.
Ergothioneine, binding specifically with OCTN-1, penetrates mitochondria to efficiently neutralize free radicals and activate other antioxidants.
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Ergothioneine transporter OCTN1
Expression of ergothioneine transporter OCTN1 on stratum corneum cells (green)
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Unique Benefits Of ErgoElite™ L-Ergothioneine
In Food & Supplements
Unparalleled Comprehensive Health Effects
DNA Level
King of AntiOxidant
.
Delay Aging
.
Boost sleep, conquer fatigue
.
Enhance Mind, Heart, Mood
.
L-Ergothioneine VS. Other Antioxidants >6*Glutathione, >6*Astaxanthin 46*Coenzyme Q10, >3028Vitamin E
L-Ergothioneine: Transforming Anti-Aging Skincare with Superior Antioxidant Power
In the dynamic and competitive landscape of the beauty industry, the demand for effective anti-aging solutions is incessant. L-Ergothioneine distinguishes itself as a powerful antioxidant amino acid, rapidly becoming indispensable in skincare formulations. This compound sets itself apart from other antioxidants by its absence in human biosynthesis, underscoring the necessity of its external application for maintaining skin health. It effectively combats oxidative stress, mitigates visible aging signs such as wrinkles and fine lines, and fosters a rejuvenated skin appearance through enhanced collagen synthesis and UV defense mechanisms.
The integration of L-Ergothioneine into skincare products enables brands to offer significant anti-aging advantages, pioneering advancements in skincare treatments that provide tangible benefits. Notably, L-Ergothioneine’s antioxidant capability far surpasses that of other well-known antioxidants; DPPH assay results reveal its free radical scavenging capacity is sixfold greater than that of glutathione and astaxanthin, impressive forty-sixfold higher than coenzyme Q10, and impressive 3028 greater than Vitamin E. This remarkable efficacy solidifies L-Ergothioneine\’s role as a revolutionary ingredient in anti-aging skincare, promising a future where skincare solutions not only promise but deliver profound anti-aging results.
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The DPPH test results show that at the same concentration, L-Ergothioneine's ability to scavenge free radicals >6 times of Glutathione >6 times of Astaxanthin > 46 times of Coenzyme Q10
The DPPH test results show L-Ergothioneine's ability to scavenge free radicals >3028 times of Vitamin E
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Delay Aging
EGT Extendslifespan by 40% on a mouse model
Professor Pinghua Liu from Boston University has shared groundbreaking research findings: Ergothioneine can extend the lifespan of mice by 40%.
EGT Extendslifespan by 40% on a mouse model
Ergothioneine combats aging by reducing inflammation, slowing telomere shortening, enhancing skin properties, and preventing neurodegenerative diseases and fibrosis.
Ergothioneine prolongs life by maintaining mitochondrial health.
The study indicates that ergothioneine prolongs life by maintaining mitochondrial health. Literature reveals that ergothioneine regulates peroxisomal fatty acid oxidation to sustain normal mitochondrial function, thereby extending lifespan.
Ergothioneine can regulate peroxisomal fatty acid oxidation to maintain normal mitochondrial function and extend lifespan.
Boost Sleep, Conquer Fatigue Supassing VC, Niacinamide, Decrease Melanocytes Hugely
Professor Takahiro Ishimoto from the School of Pharmacy at Kanazawa University in Japan conducted a study involving 92 volunteers with high anxiety and sleep issues. Over four weeks, participants took daily 20mg doses of EGT or a placebo. The study found that ergothioneine significantly improved human sleep difficulties through various biological mechanisms.
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Improve Nervous System
Decrease Cardiovascular Diseases
Anti-Depression
Reduced levels of ergothioneine may weaken antioxidant capacity,
increasing the risk of neurological and cardiovascular diseases.
Oxidative stress leads to protein denaturation, lipid peroxidation, and DNA damage, thereby inducing the occurrence of various diseases in the human body, including diabetes, cardiovascular diseases, neurodegenerative diseases, among others. Studies have shown that ergothioneine plays a beneficial role in oxidative stress-related diseases.
The National University of Singapore conducted a 9-year follow-up study on 496 participants and found that the plasma levels of ergothioneine in people with dementia were significantly lower than those in normal people; the levels of ergothioneine in the plasma of patients with hypertension, diabetes or cardiovascular disease significantly reduced. Reduced ergothioneine may lead to decreased antioxidant capacity, causing neurological and cardiovascular and cerebrovascular diseases.
Intervention In Diabetes— New Drugs For Diabetes Mellitus Of Dietary Origin
The development of type 2 diabetes is strongly linked to diet, with studies showing that ergothioneine-rich supplements can benefit diabetic patients. This is due to oxidative stress, a key factor in diabetes pathogenesis, where high glucose levels lead to excessive reactive oxygen species (ROS), overwhelming the antioxidant system. Thus, ergothioneine, with its strong antioxidant properties and unique dietary sources, could serve both as a diagnostic marker and a supplementary treatment for diabetes.
![Dare A, Channa M L, Nadar A. Lergothioneine
and metformin alleviates
liver injury in experimental type-2
diabetic rats via reduction of oxidative
stress, inflammation, and
hypertriglyceridemia [J]. Can J Physiol
Pharmacol, 2021, 99(11): 1137-1147.](https://www.etprotein.com/wp-content/uploads/2024/04/diabetes-mellitus.jpg "diabetes mellitus")
Preventing Cardiovascular Diseases— Noninvasive Cardiovascular Treatments
Cardiovascular diseases are primarily ischemic or hemorrhagic conditions of the heart and systemic tissues, often caused by hyperlipidemia, increased blood viscosity, and atherosclerosis. Ischemia-reperfusion injury, catalyzed by transition metals like iron and copper forming oxygen-free radicals, is a significant cause of these diseases. Ergothioneine aids in preventing cardiovascular diseases by reducing triglyceride levels and inhibiting the oxidation of low-density lipoprotein, crucial for slowing atherosclerosis progression. A study showed that administering 10 mg/kg of ergothioneine daily for seven days to myocardial infarction rats improved echocardiography results, decreased the area of cardiac damage, and reduced fibrosis. Both in vivo and in vitro studies confirmed that ergothioneine blocks the NF-κB-dependent Wnt5a-sFlt-1 pathway and reduces glutathione sulfhydration, thereby exerting its protective effects.
![Duan R, Pan H, Li D, et al.
Ergothioneine improves myocardial
remodeling and heart function after
acute myocardial infarction via Sglutathionylation
through the NF-kB
dependent Wnt5a-sFlt-1 pathway [J]. Eur
J Pharmacol, 2023, 950: 175759.](https://www.etprotein.com/wp-content/uploads/2024/04/Cardiovascular.jpg "Cardiovascular")
Treating Neurological Disorders— Novel Approaches To Depression Treatmen
Oxidative stress plays a pivotal role in neurodegenerative diseases such as depression, Alzheimer’s, and Parkinson’s, particularly due to β-amyloid protein deposition impacting various neurological disorders. Ergothioneine is absorbed via the specific transporter protein OCTN1/SLC22A4, allowing distribution to several organs, including the brain, where it demonstrates significant therapeutic potential. Detected in animal brains, OCTN1 facilitates ergothioneine’s ability to cross the blood-brain barrier, offering protection against psychiatric disorders and showing promise in treating and preventing central nervous system diseases like cognitive dysfunction and depression. In our aging and stressful society, ergothioneine intake could be crucial in maintaining brain health and preventing neurological disorders.
Proven To Attract More Buyers And Boost Brand Reputation For Below Savvy Brands
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Efficient Food Applications Solutions Supported by Scientif Researches
Protective Effect Of Ergothioneine On Food Color Food Coloring Agents
Changes in food color are influenced by carbonyl reactions, oxidation reactions, and enzyme-catalyzed reactions. Ergothioneine, a potent antioxidant found in edible mushrooms, not only controls lipid oxidation and myoglobin oxidation in meat but also delays meat discoloration during low-temperature storage. In meat products, non-enzymatic browning due to lipid and amine oxidation contributes significantly to color and quality changes. Ergothioneine accumulation in catfish muscles inhibits lipid oxidation and delays color changes, while applying extracts from golden needle mushrooms containing ergothioneine prevents blackening of Chinese mitten crabs by reducing phenol oxidase activity.
The Anti-Lipid Peroxidation Effect Of Ergothionein Food Preservatives
Lipid peroxidation, responsible for unpleasant food odors and harmful substances, is driven by singlet oxygen (O2) production and free radical chain reactions, leading to the oxidation of lipids. Ergothioneine acts as an effective antioxidant by quenching O2 and free radicals, decomposing hypochlorous acid, and inhibiting hemoglobin compound formation, thereby preventing lipid peroxidation. Incorporating 10% Ergothionein-rich Flammulina velutipes extract into fish and beef products reduced lipid peroxide hydrogen and thiobarbituric acid reactive substance content, lowered lipid oxidation levels, and prolonged shelf life.
Protective Effect Of Ergothioneine On Other Bioactive Components Flavor Enhancers
Changes in food color are influenced by carbonyl reactions, oxidation reactions, and enzyme-catalyzed reactions. Ergothioneine, a potent antioxidant found in edible mushrooms, not only controls lipid oxidation and myoglobin oxidation in meat but also delays meat discoloration during low-temperature storage. In meat products, non-enzymatic browning due to lipid and amine oxidation contributes significantly to color and quality changes. Ergothioneine accumulation in catfish muscles inhibits lipid oxidation and delays color changes, while applying extracts from golden needle mushrooms containing ergothioneine prevents blackening of Chinese mitten crabs by reducing phenol oxidase activity.
The Preservation Effect Of Ergothioneine On Food Food Storage Agents
Lipid peroxidation, responsible for unpleasant food odors and harmful substances, is driven by singlet oxygen (O2) production and free radical chain reactions, leading to the oxidation of lipids. Ergothioneine acts as an effective antioxidant by quenching O2 and free radicals, decomposing hypochlorous acid, and inhibiting hemoglobin compound formation, thereby preventing lipid peroxidation. Incorporating 10% Ergothionein-rich Flammulina velutipes extract into fish and beef products reduced lipid peroxide hydrogen and thiobarbituric acid reactive substance content, lowered lipid oxidation levels, and prolonged shelf life.
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EGT Is So Excellent!
Why Isn't It More Commonly Used?
Too Expensive!
What We Do?
We Cut The Price To Be Less Than 5%!
How we make it happen?
Our R&D team has lowered Ergothioneine production costs using biosynthesis, optimizing raw materials and fermentation processes to increase yield and ensure safety.
Our skilled R&D team has greatly reduced Ergothioneine production costs using biosynthesis, thanks to:
Enhanced Fermentation: boost Ergothioneine yield and production efficiency.
Optimized Metabolic Pathways: By modifying microbial pathways, we increase synthetic efficiency.
Faster Production, Higher Yield: Our methods cut fermentation time to 3-9 days and achieve up to 10 g/L, lowering cost per unit.
Safety: Using edible, non-GMO raw materials ensures product safety, crucial for pharmaceuticals and aligned with safety standards.
Overall, these strategies enhance Ergothioneine yield and reduce costs, giving us a competitive edge.
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Walk Through Advanced Laboratory
Advanced equipment, High-tech methodologies, Highly educated researchers, Trustworthy partner
Our biosynthesis laboratory is outfitted with cutting-edge equipment and utilizes high-tech methodologies, ensuring that our research is conducted at the forefront of scientific innovation. Our team comprises highly educated individuals, all holding at least a master’s degree and doctor’s degree, which underpins our commitment to excellence and reliability in our field. This combination of advanced technology and skilled personnel makes our lab a trustworthy partner in biosynthesis research.
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Available Inventory and Fast Delivery Advanced equipment, Ample production capacity, Stock and Quick delivery
Our Facility is equipped with advanced equipment, and we have ample production capacity. We have stock available for orders under 10 kg, and we can deliver orders of 100KG within a 2-week timeframe.
Application Of Ergothioneine In Food: A Technical Research Guide
60 pages
E BOOK written by ET Protein R&D Team
Experience the complete journey of L-Ergothioneine with our comprehensive e-book, passionately crafted by the experts at ETprotein. Dive into the science, innovation, and dedication behind our breakthrough product. We’re thrilled to share this wealth of knowledge with you for free! Get your copy today and join us in revolutionizing health and wellness.
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1. Botta C, Di Giorgio C, Sabatier A S, etal. Genotoxicity of visible light (400-800nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and
