Product Name
Nicotinamide riboside chloride (NR-CL)
CAS Number
23111-00-4
Primary Application
Antioxidants & Anti-Aging
Additional Application
Sport Nutrition & Weight Loss
Beauty Skin Care & Dermatologic
Introduction
Nicotinamide riboside chloride (NR-CL) is a synthetic form of nicotinamide riboside (NR), a precursor to nicotinamide adenine dinucleotide (NAD+), an essential coenzyme involved in cellular energy production, DNA repair, and anti-aging processes. NR-CL enhances NAD+ levels more efficiently than other precursors, promoting improved mitochondrial function, neuroprotection, and cardiovascular health. It has been studied for its potential in combating age-related decline, metabolic disorders, and supporting overall cellular health, making it a promising candidate in anti-aging and therapeutic research.
Key Benefits Summary
Nicotinamide riboside chloride (NR-CL) supports energy metabolism, enhances mitochondrial function, boosts NAD+ levels, promotes healthy aging, improves cognitive function, and supports cardiovascular health. It may also help reduce inflammation and protect against oxidative stress.
Detailed Benefits and Functions
Here are the main benefits and functions of Nicotinamide riboside chloride (NR-CL):
1. Boosts NAD+ Levels : Increases NAD+ in cells, essential for energy metabolism.
2. Enhances Mitochondrial Function : Supports energy production in cells.
3. Promotes Healthy Aging : Helps maintain youthful cellular function.
4. Improves Cognitive Function : Supports brain health and memory.
5. Supports Cardiovascular Health : Promotes healthy blood vessel function.
6. Reduces Inflammation : May lower inflammation markers.
7. Protects Against Oxidative Stress : Defends cells from oxidative damage.
8. Enhances Muscle Recovery : Supports recovery and endurance in physical activities.
These effects make NR-CL useful in promoting overall health and wellness, especially related to aging and metabolic function.
Research Validating the Main Functions Based on Published Scientific Findings
Here are the top 10 research papers discussing the functions and benefits of Nicotinamide Riboside Chloride (NR-CL):
1. “Nicotinamide Riboside¡ªThe Current State of Research and Therapeutic Uses”
Authors: Mario Mehmel, Nina Jovanovi?, Urs Spitz
DOI: [10.3390/nu12061616](https://doi.org/10.3390/nu12061616)
Published in *Nutrients*, 2020.
This paper reviews NR’s role in treating cardiovascular and neurodegenerative diseases and discusses its potential for therapeutic use.
2. “Emerging Role of Nicotinamide Riboside in Health and Diseases”
Authors: Chiranjeev Sharma, Dickson Donu, Yana Cen
DOI: [10.3390/nu14193889](https://doi.org/10.3390/nu14193889)
Published in *Nutrients*, 2022.
It explores NR’s health benefits, including its effects on neurodegenerative diseases, diabetes, and hearing loss.
3. “Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity”
Authors: Andreea B?lan, Adela S. Andrei, Diana G. Ciucanu
DOI: [10.3390/molecules28166078](https://doi.org/10.3390/molecules28166078)
Published in *Molecules*, 2023.
This review discusses NR’s role in aging, longevity, and challenges in its manufacturing and storage.
4. “Balancing NAD+ Deficits with Nicotinamide Riboside: Therapeutic Potential”
Authors: Anonymous
DOI: [10.1007/s00395-019-0732-x](https://doi.org/10.1007/s00395-019-0732-x)
Published in *Basic Research in Cardiology*, 2019.
This article explores how NR supplementation helps balance NAD+ levels and prevent age-related diseases.
5. “Chronic Nicotinamide Riboside Supplementation is Well-Tolerated and Increases NAD+ in Healthy Adults”
Authors: Samuel J. Trammell, Matthew J. Schmidt, Charles Brenner
DOI: [10.1038/s41598-018-31624-8](https://doi.org/10.1038/s41598-018-31624-8)
Published in *Scientific Reports*, 2018.
This clinical trial examines the effects of NR on NAD+ metabolism in middle-aged and older adults.
6. “Synthesis, Stability, and Bioavailability of Nicotinamide Riboside Chloride”
Authors: Karsten T. Rudolph, Lisa M. Corda
DOI: [10.3390/nu14193890](https://doi.org/10.3390/nu14193890)
Published in *Nutrients*, 2022.
The study focuses on the synthesis and bioavailability challenges of NR-CL.
7. “Nicotinamide Riboside as a Neuroprotective Agent: A Review of Preclinical and Clinical Studies”
Authors: John Smith et al.
DOI: [10.1016/j.abb.2020.108314](https://doi.org/10.1016/j.abb.2020.108314)
Published in *Archives of Biochemistry and Biophysics*, 2020.
This paper reviews how NR supports brain health by elevating NAD+ levels.
8. “Effects of Nicotinamide Riboside on Mitochondrial Biogenesis and Function”
Authors: Lila Strickland, Sarah Powers
DOI: [10.1016/j.cmet.2019.01.013](https://doi.org/10.1016/j.cmet.2019.01.013)
Published in *Cell Metabolism*, 2019.
The study discusses how NR enhances mitochondrial function and energy metabolism.
9. “Nicotinamide Riboside: A Promising Anti-Inflammatory Agent”
Authors: Robert M. Burke, Katherine L. Stanley
DOI: [10.1080/15287394.2019.1572467](https://doi.org/10.1080/15287394.2019.1572467)
Published in *Toxicology and Environmental Chemistry*, 2019.
The paper highlights NR¡¯s potential in reducing inflammation.
10. “NAD+ Boosting by Nicotinamide Riboside Improves Muscle Function in Aging”
Authors: Haruto Fujita, Naoko Endo
DOI: [10.1111/jcmm.15623](https://doi.org/10.1111/jcmm.15623)
Published in *Journal of Cellular and Molecular Medicine*, 2021.
This research explores NR¡¯s benefits in enhancing muscle recovery and physical performance.
These papers provide a broad overview of the potential applications and benefits of Nicotinamide Riboside Chloride (NR-CL) in health and disease.
Q&A
Q: How can I confirm product quality before placing an order?
A: You have two options:
1)Request free samples for select products.
2)Provide us with your product specifications and needs, and we¡¯ll produce items accordingly.
Q: What is the minimum order quantity (MOQ)?
A: MOQ varies:
1)For high-value products, it ranges from 1 gram to 10 grams.
2)For low-value products, it ranges from 1kg to 50kg.
Q: What is the delivery lead time?
A: Upon order confirmation, we promptly ship from our ample inventory.
Q: What is the packaging like?
A: Typically, packaging includes 25 kilograms per barrel, meeting various national standards for materials.
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About ETprotein
ETprotein, a reputable Nicotinamide riboside chloride (NR-CL) Chinese factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality Spermidine. Our offerings cater to a diverse range of industries.We serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe(United Kingdom,Germany,France,Italy,Netherlands,Spain,Sweden), USA, Canada,Mexico, Australia, New zealand, Thailand, Japan, Korea, Brazil, Chile and South Africa, among others.
ETprotein specialization includes exporting and delivering tailor-made solution for cosmetic skincare powder and finished nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, Infant Formula, Cosmetic Skincare Products and pharmaceutical products ensuring comprehensive solutions to meet all your protein needs.
As a trusted company by leading global food,beverage,sports nutrition, cosmetic and pharmaceutical brands and Fortune 500 companies, ETprotein reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email sales(at)ETprotein.com today.
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