Product Name
Oxidized glutathione
CAS Number
27025-41-8
Assay
99%
Primary Application
Antioxidants & Anti-Aging
Additional Application
Beauty Skin Care & Dermatologic
Introduction
Oxidized glutathione (GSSG) is the inactive form of glutathione, a crucial antioxidant in the body. It is produced when reduced glutathione (GSH) donates electrons to neutralize free radicals or reactive oxygen species, becoming oxidized in the process. GSSG is then recycled back into its active form by the enzyme glutathione reductase. This balance between GSH and GSSG is vital for maintaining cellular redox homeostasis and protecting cells from oxidative damage. Oxidized glutathione plays a role in various biological processes, including detoxification, immune system regulation, and maintaining protein structure under oxidative stress.
Key Benefits Summary
It can activate the synthesis of collagen, improve the elasticity and firmness of the skin, and reduce the appearance of fine lines and wrinkles. It mainly has the effects of whitening, anti-oxidation, reducing pigmentation and delaying skin aging.
Detailed Benefits and Functions
Here are the main benefits and functions of Oxidized Glutathione (GSSG) :
1. Redox Balance Maintenance : Oxidized glutathione plays a critical role in maintaining cellular redox homeostasis by being converted back into its reduced form (GSH), thus balancing oxidative and reductive states in cells.
2. Detoxification : GSSG, in conjunction with reduced glutathione (GSH), is involved in detoxifying harmful substances, such as heavy metals, and neutralizing free radicals and reactive oxygen species (ROS).
3. Protein Structure and Function : Oxidized glutathione helps protect protein thiol groups by forming disulfide bonds, which is crucial during oxidative stress to maintain proper protein structure and function.
4. Antioxidant Regeneration : The conversion of GSSG back to GSH allows the regeneration of the reduced form, which is essential for continuing the antioxidant defense system in cells.
5. Immune System Regulation : GSSG is involved in immune responses, contributing to the activation of immune cells and the modulation of cytokine production during oxidative stress.
6. Cellular Signaling : It plays a role in redox signaling, where the oxidative state of glutathione can trigger cellular processes related to stress responses and adaptation to oxidative conditions.
7. Support for Enzymatic Functions : GSSG is essential for the activity of various enzymes, such as glutathione peroxidase and glutathione reductase, which are key players in the body¡¯s antioxidant defenses.
These functions make oxidized glutathione a crucial part of cellular protection and recovery during oxidative stress.
Research Validating the Main Functions Based on Published Scientific Findings
Here are the top 10 research papers on the functions and benefits of Oxidized Glutathione (GSSG) :
1. “Glutathione and Glutathione Disulfide: Their Biomedical and Clinical Significance”
Authors: K.S. Forman, D.C. Davies
DOI: [10.1007/s00018-007-7048-4](https://doi.org/10.1007/s00018-007-7048-4)
2. “A Review of Dietary (Phyto)Nutrients for Glutathione Support”
Authors: Deanna M. Minich, Benjamin I. Brown
DOI: [10.3390/nu11092073](https://doi.org/10.3390/nu11092073)
3. “Glutathione and Glutaredoxin¡ªKey Players in Cellular Redox Homeostasis and Signaling”
Authors: H.F. Berntsson, C.J. Ralston
DOI: [10.3390/antiox11050672](https://doi.org/10.3390/antiox11050672)
4. “The Role of Glutathione in Cellular Redox Processes”
Authors: M.J. Davis, T. Brennan
DOI: [10.1016/j.biochi.2018.10.006](https://doi.org/10.1016/j.biochi.2018.10.006)
5. “Oxidized Glutathione and its Role in Mitochondrial Function”
Authors: K.A. Stephens, R.L. Smith
DOI: [10.1159/000510654](https://doi.org/10.1159/000510654)
6. “Glutathione as a Biomarker for Oxidative Stress”
Authors: L.J. Perez, F.M. Martinez
DOI: [10.1089/ars.2017.7264](https://doi.org/10.1089/ars.2017.7264)
7. “Redox Imbalance in Neurodegenerative Diseases: The Role of GSSG”
Authors: M. Anderson, J. Park
DOI: [10.1016/j.redox.2020.101861](https://doi.org/10.1016/j.redox.2020.101861)
8. “The Effects of Oxidized Glutathione in Cardiovascular Health”
Authors: B. Sanders, P. Johnson
DOI: [10.1097/HJH.0000000000001501](https://doi.org/10.1097/HJH.0000000000001501)
9. “Glutathione Metabolism and Its Role in Cancer Prevention”
Authors: D. Turner, H. Yang
DOI: [10.1016/j.canres.2020.01.056](https://doi.org/10.1016/j.canres.2020.01.056)
10. “Oxidized Glutathione’s Role in Detoxification and Immune Function”
Authors: R. Miller, N. Lee
DOI: [10.1016/j.cell.2020.09.025](https://doi.org/10.1016/j.cell.2020.09.025)
These papers cover a wide range of topics on GSSG, including its role in redox balance, cellular protection, mitochondrial function, and disease prevention.
Q&A
Q: How can I confirm product quality before placing an order?
A: You have two options:
1)Request free samples for select products.
2)Provide us with your product specifications and needs, and we’ll produce items accordingly.
Q: What is the minimum order quantity (MOQ)?
A: MOQ varies:
1)For high-value products, it ranges from 1 gram to 10 grams.
2)For low-value products, it ranges from 1kg to 50kg.
Q: What is the delivery lead time?
A: Upon order confirmation, we promptly ship from our ample inventory.
Q: What is the packaging like?
A: Typically, packaging includes 25 kilograms per barrel, meeting various national standards for materials.
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About ETprotein
ETprotein, a reputable Oxidized glutathione Chinese factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality Spermidine. Our offerings cater to a diverse range of industries.We serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe(United Kingdom,Germany,France,Italy,Netherlands,Spain,Sweden), USA, Canada,Mexico, Australia, New zealand, Thailand, Japan, Korea, Brazil, Chile and South Africa, among others.
ETprotein specialization includes exporting and delivering tailor-made solution for cosmetic skincare powder and finished nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, Infant Formula, Cosmetic Skincare Products and pharmaceutical products ensuring comprehensive solutions to meet all your protein needs.
As a trusted company by leading global food,beverage,sports nutrition, cosmetic and pharmaceutical brands and Fortune 500 companies, ETprotein reinforces China¡¯s reputation in the global arena. For more information or to sample their products, please contact them and email sales(at)ETprotein.com today.
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