Study On The Expression Of Pro-Apoptotic Caspase Adapter Protein In Prostate Cancer Tissues
Keywords
Proapoptotic Caspase Adapter Protein (Pacap) Prostate Tumor Tumor Marker
Abstract
Abstract: [Purpose] To search for differentially expressed proteins between prostate tumor tissues and normal tissues. [Method] The proteomics method was used to analyze the differences in protein expression profiles between prostate cancer tissues and normal tissues, and differential proteins were screened through two-dimensional electrophoresis and identified by mass spectrometry. [Results] The two-dimensional electrophoresis map of prostate tissue was successfully constructed, and a differential protein was screened out. The differential protein was up-regulated in 17 cases (17/24, 70.8%) of prostate cancer tissues, and only in 5 cases (5/24, 70.8%). 20.8%) showed high expression in the control group, and there was a statistical difference between the two (P=0.001). It was identified that the differential protein was pro-apoptotic caspase adapter protein (PACAP). [Conclusion] Proapoptotic caspase adapter protein can be regarded as a potential prostate cancer tumor marker
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